Basic Information
VIS ID
TVIS30015896
Fusion event
HIV-CCNYL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
208589605/207724881 (Hg38)
End
208589317/207724881 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
CCNYL1
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-15a-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-10b/Upstream/455457; hsa-mir-1244-1/Downstream/29926;
Nearest TSS
ENST00000437798/Upstream/12781; ENST00000468768/Downstream/17393;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/12499, chr2-CpG: 322/Downstream/41953
Upstream sequence
TTTCCTCCTCTTCTATAGATTTAGCTTTGGAGTCAAACCCTTCTGACCATCCAAGGGCAAGCACAATTTTCCTGAGCAAATCTCAAACGGATGGTAAGAC
Downstream sequence
AATACTGTTTTTTCCTTCCAAGGAAAAGACTGAAAACTGTTTCTATTTTATTGGATGTATTATAGAAGGTATTTAGAAGAACTGATGTATTAGTTTAAAA
Target sequence
CCTGGTTTTTGTTCCACGTGTGTGGAGAGATTCTACAATTTTGCATTCCCCAGGAGTATTTTTGTATTGTCTTTATTTCCTTTATATTTATTACTAAAAACTTCTCTGAAGACTGTTAAAAGTGATTAAAATGGATGTGTATCTATTTCAGAAATCATCTTTTCTACTCACCTAAAGTGTCACGTCTTTTTCCTCCTCTTCTATAGATTTAGCTTTGGAGTCAAACCCTTCTGACCATCCAAGGGCAAGCACAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate