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TVIS30015899
Basic Information
VIS ID
TVIS30015899
Fusion event
HIV-IKZF2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
213988491/213123767 (Hg38)
End
213988605/213123767 (Hg38)
Orient
+
Location type
Intronic
Target gene
IKZF2
miRNAs that regulate target gene
hsa-mir-130b-5p
;
hsa-mir-125b-5p
;
hsa-mir-374a-5p
;
hsa-mir-627-3p
;
hsa-mir-633
;
hsa-mir-450b-5p
;
hsa-mir-6805-5p
;
hsa-mir-876-5p
;
hsa-mir-1290
;
hsa-mir-3167
;
hsa-mir-5004-3p
;
hsa-mir-506-5p
;
hsa-mir-1260a
;
hsa-mir-1260b
;
hsa-mir-6083
;
hsa-mir-5096
;
hsa-mir-3926
;
hsa-mir-4650-5p
;
hsa-mir-1972
;
hsa-mir-10b-3p
;
hsa-mir-6869-5p
;
hsa-mir-496
;
hsa-mir-942-5p
;
hsa-mir-5006-3p
;
hsa-mir-4755-5p
;
hsa-mir-8061
;
hsa-mir-4760-5p
;
hsa-mir-211-5p
;
hsa-mir-204-5p
;
hsa-mir-623
;
hsa-mir-376a-5p
;
hsa-mir-3938
;
hsa-mir-6844
;
hsa-mir-524-5p
;
hsa-mir-520d-5p
;
hsa-mir-5588-3p
;
hsa-mir-6832-3p
;
hsa-mir-3156-3p
;
hsa-mir-188-3p
;
hsa-mir-1236-3p
;
hsa-mir-877-3p
;
hsa-mir-4301
;
hsa-mir-1306-5p
;
hsa-mir-7850-5p
;
hsa-mir-1277-5p
;
hsa-mir-190a-3p
;
hsa-mir-5011-5p
;
hsa-mir-32-5p
;
hsa-mir-92a-3p
;
hsa-mir-92b-3p
;
hsa-mir-30e-5p
;
hsa-mir-30d-5p
;
hsa-mir-30b-5p
;
hsa-mir-30c-5p
;
hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10b/Upstream/197431; hsa-mir-1244-1/Downstream/634300;
Nearest TSS
ENST00000437798/Upstream/108489;
ENST00000604818/Downstream/24862;
Nearest CpG islands
None/Target,
chr2-CpG: 135/Upstream/290441
,
chr2-CpG: 39/Downstream/28259
Nearest cancer related gene
IKZF2
(TSG, No orient, 0)
Upstream sequence
AAAATAAATTCAGggtttggtttggtttggttttgttATTTACCATACTTAACATGCTTTACTTGCAGCTGTTGGTACAAAGGTGGAAAAAGACATAATA
Downstream sequence
AAGCACTAATACATAACAAAGCATCTAAAACTTGTGAGATATTTAGCTTGAGTCTTAGTGAAAAAAAAAAGCAGTgacatttcagacaggcagatgaggg
Target sequence
TATATGTTAAGCACTACACCTAGAGCATCATTCCTCAGAAGAAATGATGATAGTATTCTAAATACAAGGGCCAATGCAAAACACTCTAAAAACCTACATGAAAGCCTGCTCTAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT3
Sample type
PBMC
Age
52
Gender
Male
CpG Island Information
×
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