Basic Information
VIS ID
TVIS30015911
Fusion event
HIV-GPCPD1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5562184/5581538 (Hg38)
End
5562258/5581538 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPCPD1
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-203a-3p ; hsa-mir-510-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-7848-3p ; hsa-mir-3143 ; hsa-mir-1184 ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-590-3p ; hsa-mir-543 ; hsa-mir-10b-5p ; hsa-mir-504-5p ; hsa-mir-10a-5p ; hsa-mir-103a-3p ; hsa-mir-107
Nearest miRNA
hsa-mir-103a-2/Upstream/1663967; hsa-mir-1-1/Downstream/1790070;
Nearest TSS
ENST00000382410/Upstream/6030; ENST00000378979/Downstream/4499;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/264386, chr20-CpG: 69/Downstream/29075
Upstream sequence
TGTTCTACTAGGGATCACTGTTACACTTCCAAAGCGTCACTTTAGATATTCAGCTGCAACTAGTTATGCCACTAGTGCCGGGGGTGTGAGATATCAGAAG
Downstream sequence
GACAACACTGTTGGCATTAACTTGAAGCTACTCACCTACTTAACATAGGTAATAAAATGTTCATAAATACCAGAGAAGCTGTCAACTGTTTTGGATCTAA
Target sequence
GTAAGAACAGAACTGTGAGTCAGAGCCATATTCTCAAATTTATATATTCTGCCATAAATAAACTGCATGATCGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate