Basic Information
VIS ID
TVIS30015913
Fusion event
HIV-XRN2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
21345760/21365122 (Hg38)
End
21345648/21365122 (Hg38)
Orient
-
Location type
Intronic
Target gene
XRN2
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-760 ; hsa-mir-186-5p ; hsa-mir-4477a ; hsa-mir-606 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-103a-2/Upstream/2894431; hsa-mir-1-1/Downstream/4843064;
Nearest TSS
ENST00000382410/Upstream/61418; ENST00000552439/Downstream/32696;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/61314, chr20-CpG: 53/Downstream/26281
Upstream sequence
TTAAAATAAGAGCTAATCTGCCTCAAGATGCTTTGGGGTTTTTGCAGTGGACTGAACAAAATTAAAGGTTATTTTATTTTTATTTTTTGTTGTTGTAAAC
Downstream sequence
CTCTTCGACCTGTCTACAATATCATTTTGAAATTTGAGTTGGGGCAATGTCTGTTACTTCTCTGTCATCACCAATAGTCAGCTAGAACATAACTTTTCCC
Target sequence
ATCTTTTCTTTATTAAAATAAGAGCTAATCTGCCTCAAGATGCTTTGGGGTTTTTGCAGTGGACTGAACAAAATTAAAGGTTATTTTATTTTTATTTTTTGTTGTTGTAAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate