Basic Information
VIS ID
TVIS30015918
Fusion event
HIV-CPNE1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
34234466/35646544 (Hg38)
End
34234330/35646544 (Hg38)
Orient
-
Location type
Intronic
Target gene
CPNE1
miRNAs that regulate target gene
hsa-let-7d-5p ; hsa-mir-1229-3p ; hsa-mir-500a-5p ; hsa-mir-532-5p ; hsa-mir-378a-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/192447; hsa-mir-1-1/Downstream/2870019;
Nearest TSS
ENST00000382410/Upstream/13990; ENST00000397416/Downstream/7133;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/26785, chr20-CpG: 46/Downstream/18090
Upstream sequence
attcctgggctcaagcgatcctcccacctcggcctcccaaagtgctgggattacaggtgtgacccaccacacccagccTGACAAGTCTTATCCACCAATC
Downstream sequence
AAAAGCTATGAATGAACTACTCCCACCCATTAGGAGGCTGAGGCTAGAGACAGCAGTGAAGGGGCTTCAGTCTAAGAGTTTTAAGTCCTGGTTACGAGCA
Target sequence
agacagggtcttgctatgttactcacgctagtctcaattcctgggctcaagcgatcctcccacctcggcctcccaaagtgctgggattacaggtgtgacccaccacacccagccTGACAAGTCTTATCCACCAATC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate