Basic Information
VIS ID
TVIS30015924
Fusion event
HIV-TOP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
GRCh37/hg19
Start
39704657/41076017 (Hg38)
End
39704624/41076017 (Hg38)
Orient
-
Location type
Intronic
Target gene
TOP1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-374a-5p ; hsa-mir-23a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/2559385; hsa-mir-1-1/Downstream/93006;
Nearest TSS
ENST00000382410/Upstream/47199; ENST00000490253/Downstream/60943;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/46245, chr20-CpG: 175/Downstream/60572
Upstream sequence
CTGTGTATTCTTAGTCACTTTAAAAAAAATGTCCTGGTGTGTCTAGAATGATGGTTTCTGTTCTTTGCAAAAATAAAAACATCAAACAAGATAAAGTCCG
Downstream sequence
ATGTAGCCAAGACCCTCTACTTGAACCTTCTGTCGGTACTGTTTGTTTAAGTACTGTAAGTTTCCACGGTTCATGTTATCTTAGGATATCTTGTGAAACG
Target sequence
CAAAAATAAAAACATCAAACAAGATAAAGTCCG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate