Basic Information
VIS ID
TVIS30015926
Fusion event
HIV-ZHX3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
GRCh37/hg19
Start
39891370/41262730 (Hg38)
End
39891203/41262730 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZHX3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-877-3p ; hsa-mir-3171 ; hsa-mir-4778-5p ; hsa-mir-100-3p ; hsa-mir-548e-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-1183 ; hsa-mir-4793-3p ; hsa-mir-3130-3p ; hsa-mir-6749-3p ; hsa-mir-6826-3p ; hsa-mir-3117-5p ; hsa-mir-150-5p ; hsa-mir-6887-3p ; hsa-mir-6795-3p ; hsa-mir-186-3p ; hsa-mir-483-3p ; hsa-mir-425-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/93652; hsa-mir-1-1/Downstream/3145390;
Nearest TSS
ENST00000382410/Upstream/58689; ENST00000445975/Downstream/9515;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/124538, chr20-CpG: 121/Downstream/54224
Upstream sequence
CATCAAccttgaaggcagggacagaattgcctttacttttgtatctcctgcacccagctcaggatctgttggctcagagtgagacctcagtggttgttaa
Downstream sequence
ctaactgaatCAAAAAATAGCAAAATACTTATGAGTACCAGGCTGAGGCTCAGAAGAATTAAGACACTTCACAGAACAAACATTAAGGGGTGAAAAAAAA
Target sequence
tGTATCCAGTACACCTGACACATCACATCTTTTGCCATTGTTGGCTGATTTGCACATCATGCCACCTCATCAAccttgaaggcagggacagaattgcctttacttttgtatctcctgcacccagctcaggatctgttggctcagagtgagacctcagtggttgttaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate