Basic Information
VIS ID
TVIS30015934
Fusion event
HIV-PABPC1L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
43561095/44932454 (Hg38)
End
43561385/44932454 (Hg38)
Orient
+
Location type
Intronic
Target gene
PABPC1L
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/524251; hsa-mir-1-1/Downstream/493056;
Nearest TSS
ENST00000382410/Upstream/275; ENST00000465761/Downstream/228;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/22035, chr20-CpG: 56/Downstream/27625
Upstream sequence
CTGCATACTATGGCTGTGGCCCAGTGACACCCACCCAGCCTGCCCCCAGGTGGACATCCCAGCCACCTAGACCTTCCTGTGAGTGACCCAGCCCCTTCCA
Downstream sequence
AGGCCCTCCTCTGTAAGAGTGAATTGCACGCTCACTTGAAACTATCTTGAGGGACTAAGGTGTACAATCCTGGTGCTTATGCAGTTTGGGGCTCTAGGTA
Target sequence
CTCTCAGACTGGCCTATTGGTGTGGGCCCCGTGAGGCAGTCATAACACAGGGATgaaacctggctctgccacttcccaaggtgggtgacttcacttctctgagcctcagtttcctcttctgagcatgggCCTGAATGAGACGTGTGTAAAGTACCAAGCACAGTGGTGAGCCAATGGAAGACACGCAGCTAGCCACCAGCAGTCATCACCAAAGATGCCTCTGATTTGTGACTCTGAAAATTCTTGCAAAGCTGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate