Basic Information
VIS ID
TVIS30015937
Fusion event
HIV-NCOA3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
End
46206917/47577992 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-18a-5p ; hsa-mir-29b-3p ; hsa-mir-17-5p ; hsa-mir-33a-5p ; hsa-mir-590-3p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-744-5p ; hsa-mir-20a-5p ; hsa-mir-548c-3p ; hsa-mir-219a-1-3p ; hsa-mir-571 ; hsa-mir-758-3p ; hsa-mir-1252-3p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-137 ; hsa-mir-126-5p ; hsa-mir-378a-5p ; hsa-mir-608 ; hsa-mir-1200 ; hsa-mir-302f ; hsa-mir-3664-5p ; hsa-mir-3941 ; hsa-mir-4641 ; hsa-mir-4651 ; hsa-mir-219b-3p ; hsa-mir-4690-3p ; hsa-mir-4731-5p ; hsa-mir-4789-3p ; hsa-mir-4795-3p ; hsa-mir-5685 ; hsa-mir-6856-3p ; hsa-mir-8485 ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-214-3p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-342-5p ; hsa-mir-181d-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-3150b-3p ; hsa-mir-3927-3p ; hsa-mir-4433a-3p ; hsa-mir-4455 ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-4664-5p ; hsa-mir-4689 ; hsa-mir-4722-5p ; hsa-mir-4784 ; hsa-mir-6165 ; hsa-mir-6737-5p ; hsa-mir-6747-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6831-5p ; hsa-mir-6858-5p ; hsa-mir-7155-5p ; hsa-mir-580-3p ; hsa-mir-4324 ; hsa-mir-4251 ; hsa-mir-382-3p ; hsa-mir-4495 ; hsa-mir-4803 ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-30d-5p ; hsa-mir-4642 ; hsa-mir-488-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-4796-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-544b ; hsa-mir-224-5p ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-5589-5p ; hsa-mir-4524b-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-219a-2-3p ; hsa-mir-17-3p ; hsa-mir-20b-3p ; hsa-mir-3529-5p ; hsa-mir-379-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/410934; hsa-mir-1-1/Downstream/2285867;
Nearest cancer related gene
NCOA3(OG, No orient, 0)
Upstream sequence
CAGCTTGATTCTTTCTAGTATATATCACAAGATATGTGGTAATACCTGTCTTTATTTTACTAGACATGCATATGCTGTAATTTGAAATAATTCCTTGTCC
Downstream sequence
TTTTATATAACTTTATTATTATTAttttttaagacagagtcttgctctgttgcccaggctggagtgcagtggcgcgatctcagctcactgcaacctctgc
Target sequence
CCCACTCCCTTATCAAGAAGATTATAGCATTTAAAAAAGATTGTTATAAATGTCTTACCAATGTTCTCCTGGGAAGCAAATACATTTTTACTTAATTGAACATACAATAATGGACTAAGTAATGGGAAAAAAAAATTCTTAAACTGAGTTAAGTTTATATAGCTCAAAAAAAGTGGTACCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate