Basic Information
VIS ID
TVIS30015939
Fusion event
HIV-ADNP integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
49522968/50906431 (Hg38)
End
49523154/50906431 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADNP
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-328-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/291646; hsa-mir-1-1/Downstream/546474;
Nearest TSS
ENST00000382410/Upstream/873; ENST00000614698/Downstream/3360;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/65626, chr20-CpG: 143/Downstream/24100
Upstream sequence
GTATTAAAATGGATGCCCACAGATACCTAAGACTGGGAAGAGACATCTTGTTTCTCTGTTCATTTCATAAACTCTCTATGGGCCAAAATTCAGTTCTTTG
Downstream sequence
GCAGCTTGGGGGAAAGAAAAACCCATTCTTCTAAGTGCCTACCCACAGCTTAAAAAGTCGGTTTAAGACATTAAGATGAAGCATCTCACTGCCTGGTAGG
Target sequence
GGAACTTCCTGAGTTAACTCTGCTTCACACTTCATAACAGATGTGTCCAGAAGCCAGCCATTAATGGTTTCCCTGCCTCCTGGATGAGTGGCTCAACAATCTCAGAAAAACAAAGACATAAAGATTTGGAAATGCAGCCACCACTGGGGTCATTAGTCTATAGAAAACATAAAAAAGAATCAAGCG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate