Basic Information
VIS ID
TVIS30015943
Fusion event
HIV-ZNF831 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
57778717/59203662 (Hg38)
End
57778586/59203662 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF831
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4470 ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-6865-3p ; hsa-mir-34b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/385349; hsa-mir-1-1/Downstream/1104812;
Nearest TSS
ENST00000382410/Upstream/12642; ENST00000371025/Downstream/96765;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/10821, chr20-CpG: 25/Downstream/18506
Upstream sequence
ctaaaatatttattagctggacctttgcataaaaatcaagcagacccctgCATTAATCCACTTTTGCCCACTTACATGTTAAATTTTAGCTTCCCGTTTA
Downstream sequence
TACTTGAAGTTTTTTTCAGGGCCTTTCATTCTGCTTTCATTCATCTCTATGTTTTTTGCCAACTGCAAATACCACACTGTAATGAAAATGGTTGTTTTCA
Target sequence
cgtggcacagattgtctgtggcatacaaagtctaaaatatttattagctggacctttgcataaaaatcaagcagacccctgCATTAATCCACTTTTGCCCACTTACATGTTAAATTTTAGCTTCCCGTTTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate