Basic Information
VIS ID
TVIS30015950
Fusion event
HIV-chr21 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
16030088/14657767 (Hg38)
End
16030340/14657767 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA21A
Nearest miRNA
hsa-mir-10396a/Upstream/933493; hsa-let-7c/Downstream/1881322;
Nearest TSS
ENST00000624081/Upstream/14634; ENST00000430391/Downstream/1054;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/274002, chr21-CpG: 171/Downstream/406408
Nearby gene
SAMSN1(No orient, 111424)
Upstream sequence
ATACCACTTAAATCACCTGAAATGGGATTTCTGCCATCAGATTTATACGGCACAAAGCAAAGTTGAGAGCTGGCAGTTATTTTGTAAATTGGACTATATG
Downstream sequence
ATAGACATAATGCCCTGCTGTAAACACAGAAATGAATAAAATTATTTTTGAAATCCATTTTTAAGCATTGGCAGATGGTCACAATTGCAGGTTAGAGTTA
Target sequence
GGCAACAAGAACTCGATGATTCAGCCTCCCACAACTCATAATTGCATTTTATTTTTCAAGATGCTCTAAGATTAAACCCCTTATCTTGGCTTAAAATGCCTCCTGTTTAGGTATTACAACGTATGTCAGCACCATCTCTACTGCTTATGTTAATCTTATGTGCAATTAGGAAAGAAAACAAACATCAGAACTAGGCCATCTTACTTTCCCAAATGAGAGGGATCTCCCATCGACATCTTGAAAAACCAATGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate