Basic Information
VIS ID
TVIS30015955
Fusion event
HIV-VPS26C integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.13
Reference genome
GRCh37/hg19
Start
38620652/37248351 (Hg38)
End
38620845/37248351 (Hg38)
Orient
+
Location type
Intronic
Target gene
VPS26C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-877-5p ; hsa-mir-4314 ; hsa-mir-4471 ; hsa-mir-8059 ; hsa-mir-1292-5p ; hsa-mir-203a-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3192-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-665 ; hsa-mir-6771-5p ; hsa-mir-5192 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-485-5p ; hsa-mir-6884-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-4768-3p ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-let-7c/Upstream/1527543; hsa-mir-3197/Downstream/2198659;
Nearest TSS
ENST00000624081/Upstream/14909; ENST00000608405/Downstream/18802;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/26978, chr21-CpG: 32/Downstream/9400
Upstream sequence
aatatgctcttttcagtgtccatgatatacTTTTAAAAACTGGCCAAACTGATCCCTTAATAAGTCCAATAGGTCTTTCTTCTGGGGGTGGGGGGAGGGG
Downstream sequence
aaatcactccaagggagacatgaaatccaagcaaatcaatcatcatagaaaaaataaagttctaaataaggcccccaaacccgacagcttcacaggagat
Target sequence
GGGAACAAAGCAAATTATTAAATAATCTAATCaaaaaagaaaaacacaaatatccaaaataagaaataagagcagaaatactagaaaaatggaggtaattaaaagataatattcaacactattcaactgtatataagtaaatttgaaaagctgactaagtgaattatttttctgggaaaatataatttatcca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate