Basic Information
VIS ID
TVIS30015962
Fusion event
HIV-AGPAT3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
45295997/43876116 (Hg38)
End
45296033/43876116 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGPAT3
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-18a-3p ; hsa-mir-149-5p ; hsa-mir-100-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p
Nearest miRNA
hsa-let-7c/Upstream/266127; hsa-mir-6815/Downstream/1602150;
Nearest TSS
ENST00000624081/Upstream/8874; ENST00000498670/Downstream/6428;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/10098, chr21-CpG: 24/Downstream/67476
Upstream sequence
aaggtcaagtgatcctctcacctcagcctcccaagtgctgggattacaggcaccatgcccagcctaacctgttcttttaattttcatttttttaatagtt
Downstream sequence
ccaagtttgcctctcctcttgtttggtattcttttccttacacttatttttattttctctttatgtctaaacatacttattttctatactgtaactaata
Target sequence
atatttttcattcctgaaagttctctttgttttttt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate