Basic Information
VIS ID
TVIS30015964
Fusion event
HIV-PTTG1IP integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
46279097/44859182 (Hg38)
End
46278808/44859182 (Hg38)
Orient
-
Location type
Intronic
Target gene
PTTG1IP
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-98-5p
Nearest miRNA
hsa-let-7c/Upstream/1249193; hsa-mir-6815/Downstream/619084;
Nearest TSS
ENST00000624081/Upstream/40403; ENST00000609694/Downstream/2751;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/9834, chr21-CpG: 223/Downstream/13612
Nearest cancer related gene
PTTG1IP(OG, No orient, 0)
Upstream sequence
AGGCGTCCCTGAGTGGCAGCATGGCTGAACAGCTGTAGAACACTGCACGAGAAAGATAACTGGTGCAGGCAATTGACACGAATCTCGGGCACATGCTGAA
Downstream sequence
TAAAACATCCAATAAAGCACAGGATTTCCTCCACATAAAGGCGGGAACCAGTAACATTAATCTGTGGTGACGGGAAGTCCAGTCAGTGGCTCCCATGGGG
Target sequence
gcaaccaagtcccacattgcctgagggaggccaaactggtacagccactccaaaaacatttggcagacgtactaaggctaaacacaaatatgctccgtgacacagcaactccacccctaCACTCCTCCAGACGTGAGCGCCTGTGCCGGCACCAACACAACACCGCTCACAGCAGCACCAGAAGGACCCAGGCGTCCCTGAGTGGCAGCATGGCTGAACAGCTGTAGAACACTGCACGAGAAAGATAACTGGTGC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate