Basic Information
VIS ID
TVIS30015987
Fusion event
HIV-GNB1L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
19803165/19815642 (Hg38)
End
19803316/19815642 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNB1L
miRNAs that regulate target gene
hsa-mir-6809-3p ; hsa-mir-4768-5p ; hsa-mir-6833-3p ; hsa-mir-4684-5p ; hsa-mir-7108-5p ; hsa-mir-6765-5p ; hsa-mir-663b ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-6087 ; hsa-mir-4252 ; hsa-mir-3197 ; hsa-mir-4677-3p ; hsa-mir-212-5p ; hsa-mir-6749-5p ; hsa-mir-5587-3p ; hsa-mir-5690 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-4717-5p ; hsa-mir-3926 ; hsa-mir-1250-5p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-4701-5p ; hsa-mir-4746-3p ; hsa-mir-548s ; hsa-mir-588
Nearest miRNA
hsa-mir-3198-1/Upstream/1834681; hsa-let-7a-3/Downstream/148111;
Nearest TSS
ENST00000624155/Upstream/50563; ENST00000467943/Downstream/39164;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/26711, chr22-CpG: 122/Downstream/38718
Upstream sequence
CCTGCGGGGAGTGGAGGACTGACTTGTTTTTCCAGGAACTTTAACAttttttttctttgagacaatatcttgatttgttgcccagggtggagtgcagtgg
Downstream sequence
ttggtctcgaactctgggcccaagcacacctcagcctccctaagtgctgggattacaggagtgagccactgtgcccagcttaactttttattttgaatca
Target sequence
ggtgatcacagctcactgcagcctcaaactcctccctcagatgatcctcccacttcagcctcccaagtagctgggactaccagcatgtgccaccacacccagctaatttttgtattttttgtagagacgagatttcaccatgtttcccagg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate