Basic Information
VIS ID
TVIS30015989
Fusion event
HIV-UBE2L3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
21955764/21601475 (Hg38)
End
21955643/21601475 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE2L3
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-423-5p ; hsa-mir-93-5p ; hsa-mir-125a-5p
Nearest miRNA
hsa-mir-1286/Upstream/567203; hsa-let-7a-3/Downstream/51506;
Nearest TSS
ENST00000624155/Upstream/33745; ENST00000425975/Downstream/28537;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/33049, chr22-CpG: 159/Downstream/27022
Upstream sequence
gatctcagctcactgcaacctctgtttcatgggttcaagtgattctcctgcctcagcctcctaagtagctgggattacaggcgtgtaccactacgcctgg
Downstream sequence
ctaatttttttgtatttttagtagagatgggatttcaccatgttggtcaggctggtcttgaactcctgacttcaagtgatccactcacctcagcatccca
Target sequence
caggctggagtgcagtggtgtgatctcagctcactgcaacctctgtttcatgggttcaagtgattctcctgcctcagcctcctaagtagctgggattacaggcgtgtaccactacgcctgg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate