Basic Information
VIS ID
TVIS30015990
Fusion event
HIV-KIAA1671 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
25496460/25100493 (Hg38)
End
25496878/25100493 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIAA1671
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-1226-3p ; hsa-mir-940 ; hsa-mir-92b-5p ; hsa-mir-93-3p ; hsa-mir-590-5p ; hsa-mir-551b-3p ; hsa-mir-503-5p ; hsa-mir-423-3p ; hsa-mir-326 ; hsa-mir-192-5p ; hsa-mir-29b-3p ; hsa-mir-92a-3p ; hsa-mir-30a-3p ; hsa-mir-4252 ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-6777-3p ; hsa-mir-508-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-6818-3p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-223-5p ; hsa-mir-6895-3p ; hsa-mir-593-3p ; hsa-mir-5011-5p ; hsa-mir-335-3p ; hsa-mir-376a-3p ; hsa-mir-376b-3p ; hsa-mir-500a-3p ; hsa-mir-767-5p
Nearest miRNA
hsa-mir-1286/Upstream/2214114; hsa-let-7a-3/Downstream/355153;
Nearest TSS
ENST00000624155/Upstream/30524; ENST00000637069/Downstream/11349;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/72230, chr22-CpG: 62/Downstream/78416
Upstream sequence
GAGTGGAAGGGAGGAGGAACACAGGGCAAGGTCTTCCCTCCTATGACCACATCTTCTGTACCCCATAATCCAGCTGACACAAATGGGGGTATTcacaggg
Downstream sequence
TACTCATGGAGACCTTTATAATCTCGGAGTGTTGCTTAGAGGGCAGTTCAGCCAAGTAAAGCAAACTCACTGGTCAGAAATACATTGCTTAGGGGAGGTC
Target sequence
gcagggtagcccggtggttaagggcccaggctttgagttccacccagccgtgggttgtgtcacagctctgcacatagcagatgcatgacttggactagtgatgtcattgtccagagcctctgttgtcccatctgtacaatggagattacagccttcctgggttatACCTGTCAACGAGGCAGTAGGGCGCACAGTAGGCCCTTGGTGAATGACAGCTACTGTGAGTTGAGACTATGCTTACTACAAACCCCAAGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate