Basic Information
VIS ID
TVIS30015995
Fusion event
HIV-THOC5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
29912302/29516313 (Hg38)
End
29912350/29516313 (Hg38)
Orient
+
Location type
Intronic
Target gene
THOC5
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-615-3p ; hsa-mir-186-5p ; hsa-mir-30a-3p ; hsa-let-7f-5p ; hsa-let-7b-5p ; hsa-mir-5089-5p ; hsa-mir-6842-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6778-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-4740-3p ; hsa-mir-6504-3p ; hsa-mir-7703 ; hsa-mir-6807-5p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-6863 ; hsa-mir-510-5p ; hsa-mir-1227-3p ; hsa-mir-1254 ; hsa-mir-3116 ; hsa-mir-3690 ; hsa-mir-4638-3p ; hsa-mir-508-5p ; hsa-mir-517a-3p ; hsa-mir-517b-3p ; hsa-mir-517c-3p ; hsa-mir-6501-3p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-766-3p
Nearest miRNA
hsa-mir-1286/Upstream/1056365; hsa-let-7a-3/Downstream/490736;
Nearest TSS
ENST00000624155/Upstream/4871; ENST00000403999/Downstream/20425;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/35060, chr22-CpG: 30/Downstream/37176
Upstream sequence
gtcacttattaggagaaagggaataaagtgggatagggaggcctcaactgtatctgaaatattcagtttcttcagaaTTTTTTTTTTAAAAGACATGAAG
Downstream sequence
AAAGAGTTCAGCCTTTCCTTACAGTTCTGGAACTGTCTTAGAACTACAGACAACTTCCTCAGCTCAGCACCAAGTCTTGAGGGTGTCAGATCCCACGGGC
Target sequence
AATAGAAAGAGAAGAAAGTGGGGTAGTGAGGACAGAAACTCTGATACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate