VISDB - VIS Detail

Basic Information

VIS ID

TVIS30015996

Fusion event

HIV-MTMR3 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr22

Cytoband

q12.2

Reference genome

GRCh37/hg19

Start

30307780/29911791 (Hg38)

End

30307942/29911791 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA22B

Target gene

MTMR3

miRNAs that regulate target gene

hsa-mir-181a-5p ; hsa-mir-877-5p ; hsa-mir-423-5p ; hsa-mir-106b-3p ; hsa-mir-125b-5p ; hsa-mir-27b-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-99a-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-4310 ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7157-5p ; hsa-mir-218-5p ; hsa-mir-646 ; hsa-mir-490-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-503-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-196a-3p ; hsa-mir-8073 ; hsa-mir-3128 ; hsa-mir-221-5p ; hsa-mir-6884-3p ; hsa-mir-1914-3p ; hsa-mir-3188 ; hsa-mir-4257 ; hsa-mir-4636 ; hsa-mir-5194 ; hsa-mir-595 ; hsa-mir-6736-3p ; hsa-mir-6738-5p ; hsa-mir-6847-5p ; hsa-mir-6866-5p ; hsa-mir-6873-5p

Nearest miRNA

hsa-mir-1286/Upstream/1451843; hsa-let-7a-3/Downstream/95258;

Nearest TSS

ENST00000624155/Upstream/28522; ENST00000480776/Downstream/59260;

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/27922, chr22-CpG: 50/Downstream/168232

Upstream sequence

TAATCTCAGGGTAAACAATATATATAGGTACACTCAGTTTATATATGAGATAATATTCAGGATCAGTGGAGTGAAAATAGTAAAGTATCTTCCATTTTTC

Downstream sequence

TAAATATCCTCTTTATTGTTTTCTTACAAAGTAGCTATGATAAACATATAAAAGGGTCAGAAAGAGAGGGGAGAAAAACTCGGTGAAAAGTCAGACAAGA

Target sequence

AATGGCTTAGAGGGAAAAGTGTTCATAATGGGTATAGAATTAATCAGTATTCCTTTCCCATTATTTATGCCTATACAGTGTAGAAGTTTCCCTTAAAGAGCTTATCACCATAATAAGTACAATAGCAAAGATATAAAGTCAGTACTTTTCACTGATTAGGCA

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.