Basic Information
VIS ID
TVIS30015997
Fusion event
HIV-HORMAD2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
30514664/30118675 (Hg38)
End
30514391/30118675 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
HORMAD2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-580-3p ; hsa-mir-7153-5p ; hsa-mir-103a-2-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p
Nearest miRNA
hsa-mir-1286/Upstream/111562; hsa-let-7a-3/Downstream/612882;
Nearest TSS
ENST00000624155/Upstream/24717; ENST00000447565/Downstream/88434;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/38134, chr22-CpG: 19/Downstream/125065
Upstream sequence
aaaaacagggaccttttctgtcttgttcaccgctgtgactccagtgactggcacaaagtagacattcaatacaatatttgttacatgaatgaatGGTTTC
Downstream sequence
TCAACTGTTTCCACTGTTGTTTACCTAGTTTGGTTAGATATTTGACTCTGTGATTTTGTTTTTCCAGCTTTAAAATGGTAATAATAGTATCTTTCATCTA
Target sequence
agcaaggccttccttggcccttccaaaccaaagcagcacttgtccccttcatgtacctctctatcacagcatctgcttcttgttcacagcacttacactatcggaattagcttatttcatttgtttacttatttactgactatttcccctactggattgtatgtatattccagaaaaacagggaccttttctgtcttgttcaccgctgtgactccagtgactggcacaaagtagacattcaatacaatatttgtt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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