Basic Information
VIS ID
TVIS30016061
Fusion event
HIV-MORC2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31333612/30937625 (Hg38)
End
31333673/30937625 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA22B
Target gene
MORC2
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-6515-3p ; hsa-mir-877-3p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-3675-5p
Nearest miRNA
hsa-mir-1286/Upstream/205984; hsa-let-7a-3/Downstream/222437;
Nearest TSS
ENST00000624155/Upstream/4731; ENST00000422839/Downstream/4626;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/15123, chr22-CpG: 100/Downstream/30953
Upstream sequence
AAAAGAGGCTTGTGGGCTGATGGAAATGAGTCGGGGGGGTCCAACCACCCAACTCACCGCACTGGATGGTGGTGGGGATTTCCATAGCTCTCCGGCGTTT
Downstream sequence
CAGAACTTGATGATTCCCCTCTGGGCTGGAAAGCAAACACCGATACATCATGTTAGGAGCCAGCCTCTCTCTCTCCCTACATTCAGGTGAAGAGAAAAGG
Target sequence
GTAACGCAGCTCACTGGATGGGGGCTGGTTCCAGTTGGCAGAGAGGTAGCCAAACTCATCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate