Basic Information
VIS ID
TVIS30016063
Fusion event
HIV-SFI1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31927174/31531188 (Hg38)
End
31927347/31531188 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
SFI1
miRNAs that regulate target gene
hsa-mir-1-3p
Nearest miRNA
hsa-mir-1286/Upstream/371069; hsa-let-7a-3/Downstream/90279;
Nearest TSS
ENST00000624155/Upstream/2368; ENST00000484806/Downstream/41575;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/34077, chr22-CpG: 53/Downstream/99123
Upstream sequence
ATTCGAATGACTTTTGGAAGAGTATTTCCCTCTAAAGCCAGGTAGTATTAGCTCAGAACAACATAATTGTGTTGAGTTCATTCTAGGGTTTTCTTTTATA
Downstream sequence
taaaggttaagttttagtgttcagtggtgtggcctttagctagctactgtggccttcagcttcaaagaaaaagaaagaaaaaaaaataacaagcaagtga
Target sequence
TTAAGCCTGTATATAAACTTCATTATGGCTTGTGCTGTTACATTCCTCCCCAGCCTCCAGTAGGTAGAAGCAGTCCCTAATATAACCATGTAATACAGTGGTAACTTCATATCTGTTAGTTGACTGCAGCTGCATTcatggtgagctgtgaatgttatctacaaagtagccag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate