Basic Information
VIS ID
TVIS30016066
Fusion event
HIV-DEPDC5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
32185419/31789433 (Hg38)
End
32185634/31789433 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
DEPDC5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-1286/Upstream/167902; hsa-let-7a-3/Downstream/1647149;
Nearest TSS
ENST00000624155/Upstream/11407; ENST00000473802/Downstream/3254;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/35355, chr22-CpG: 131/Downstream/154637
Upstream sequence
cagcatagatgaatcttgaacacatgttaagtgagagaagccagacatagtggatcaaatacaaatcataagatcttatttatatgaaatgtccagaata
Downstream sequence
CCTTGATTTCACATGAAAACATTTTGATGAAAAAGTATTTGAAGTCACATTAtgtagtgtaaaagagtagagtttggattaaggcagactgggttttaaa
Target sequence
ggtaaatatataatatagagattagtggttgccagggactgagggtggggagtgactgtttcatcagtttgggatttcctgttggggtgatgaaaatgttttggatccaaataatggtgatagttatacaacattgtgaatgtattaaatgtcacGATGGCAATATTTATATGTATTTTGCCACAATTAAAAAATTATTTCATTCGATTATCTCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate