Basic Information
VIS ID
TVIS30016068
Fusion event
HIV-JOSD1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
39094499/38698494 (Hg38)
End
39094441/38698494 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
JOSD1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6771-5p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-6746-5p ; hsa-mir-6849-3p ; hsa-mir-3614-5p ; hsa-mir-6500-3p ; hsa-mir-4293 ; hsa-mir-4802-3p ; hsa-mir-4443 ; hsa-mir-3978 ; hsa-mir-7847-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-1324 ; hsa-mir-1827 ; hsa-mir-3688-3p ; hsa-mir-2392 ; hsa-mir-4524b-3p ; hsa-mir-4796-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-1286/Upstream/709641; hsa-let-7a-3/Downstream/2115389;
Nearest TSS
ENST00000624155/Upstream/9171; ENST00000470836/Downstream/1476;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/16099, chr22-CpG: 159/Downstream/1874
Upstream sequence
ctaagagtaggcctttggctctttcagggcaaatggtccatacctgtgttttacaaatcaccccaaataggttgcttccagctgtaattctggtccctat
Downstream sequence
gtggcaacaatttcacttccaagctaagagagtaagaaaaaggtcttctggaattgctaatatgcactgcttgaagaatgcttgagcttctctgcagcga
Target sequence
cctgtgttttacaaatcaccccaaataggttgcttccagctgtaattctggtccctat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate