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TVIS30016077
Basic Information
VIS ID
TVIS30016077
Fusion event
HIV-TNRC6B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
40527779/40131775 (Hg38)
End
40527626/40131775 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TNRC6B
miRNAs that regulate target gene
hsa-mir-183-5p
;
hsa-mir-7-5p
;
hsa-mir-103a-3p
;
hsa-mir-32-5p
;
hsa-mir-21-5p
;
hsa-mir-19b-3p
;
hsa-mir-18a-5p
;
hsa-mir-16-5p
;
hsa-mir-1229-3p
;
hsa-mir-744-5p
;
hsa-mir-484
;
hsa-mir-320a
;
hsa-mir-125b-5p
;
hsa-mir-23b-3p
;
hsa-mir-222-3p
;
hsa-mir-99a-5p
;
hsa-mir-31-5p
;
hsa-let-7b-5p
;
hsa-mir-18b-5p
;
hsa-mir-26a-5p
;
hsa-mir-26b-5p
;
hsa-mir-1297
;
hsa-mir-4465
;
hsa-mir-5697
;
hsa-mir-29b-1-5p
;
hsa-mir-362-3p
;
hsa-mir-329-3p
;
hsa-mir-603
;
hsa-mir-543
;
hsa-mir-3658
;
hsa-mir-3941
;
hsa-mir-6757-3p
;
hsa-mir-8485
;
hsa-mir-19a-3p
;
hsa-mir-1249-5p
;
hsa-mir-6797-5p
;
hsa-mir-4269
;
hsa-mir-3150b-3p
;
hsa-mir-4784
;
hsa-mir-6715b-5p
;
hsa-mir-520g-3p
;
hsa-mir-520h
;
hsa-mir-548at-5p
;
hsa-mir-1321
;
hsa-mir-4739
;
hsa-mir-4756-5p
;
hsa-mir-561-3p
;
hsa-mir-6756-5p
;
hsa-mir-6766-5p
;
hsa-mir-15a-5p
;
hsa-mir-107
;
hsa-mir-15b-5p
;
hsa-mir-186-3p
;
hsa-mir-195-5p
;
hsa-mir-378a-5p
;
hsa-mir-330-3p
;
hsa-mir-424-5p
;
hsa-mir-497-5p
;
hsa-mir-4310
;
hsa-mir-4729
;
hsa-mir-6838-5p
;
hsa-mir-7157-5p
;
hsa-mir-17-5p
;
hsa-mir-20a-5p
;
hsa-mir-93-5p
;
hsa-mir-106a-5p
;
hsa-mir-106b-5p
;
hsa-mir-20b-5p
;
hsa-mir-526b-3p
;
hsa-mir-519d-3p
;
hsa-mir-891b
;
hsa-mir-5586-5p
;
hsa-mir-6849-3p
;
hsa-mir-4781-3p
;
hsa-mir-3120-3p
;
hsa-mir-148a-3p
;
hsa-mir-130a-3p
;
hsa-mir-152-3p
;
hsa-mir-301a-3p
;
hsa-mir-130b-3p
;
hsa-mir-148b-3p
;
hsa-mir-454-3p
;
hsa-mir-301b-3p
;
hsa-mir-4295
;
hsa-mir-3666
;
hsa-mir-3688-3p
;
hsa-mir-4643
;
hsa-mir-506-3p
;
hsa-mir-124-3p
;
hsa-mir-5186
;
hsa-mir-1-5p
;
hsa-mir-4753-5p
;
hsa-mir-513a-5p
;
hsa-mir-6893-3p
;
hsa-mir-370-3p
;
hsa-mir-101-5p
;
hsa-mir-3151-5p
;
hsa-mir-6721-5p
;
hsa-mir-486-3p
;
hsa-mir-4722-5p
;
hsa-mir-1286
;
hsa-mir-6804-5p
;
hsa-mir-4692
;
hsa-mir-4514
;
hsa-mir-940
;
hsa-mir-6893-5p
;
hsa-mir-6808-5p
;
hsa-mir-1825
;
hsa-mir-759
;
hsa-mir-500b-3p
;
hsa-mir-4482-5p
;
hsa-mir-3130-5p
;
hsa-mir-6515-5p
;
hsa-mir-7847-3p
;
hsa-mir-7106-5p
;
hsa-mir-765
;
hsa-mir-766-5p
;
hsa-mir-4533
;
hsa-mir-6133
;
hsa-mir-6130
;
hsa-mir-6127
;
hsa-mir-6129
;
hsa-mir-4510
;
hsa-mir-4419a
;
hsa-mir-1252-5p
;
hsa-mir-6876-5p
;
hsa-mir-4476
;
hsa-mir-5089-5p
;
hsa-mir-5589-5p
;
hsa-mir-6807-5p
;
hsa-mir-4731-5p
;
hsa-mir-6506-5p
;
hsa-mir-619-5p
;
hsa-mir-512-3p
;
hsa-mir-520e
;
hsa-mir-520d-3p
;
hsa-mir-520c-3p
;
hsa-mir-520b
;
hsa-mir-520a-3p
;
hsa-mir-373-3p
;
hsa-mir-372-3p
;
hsa-mir-302e
;
hsa-mir-302d-3p
;
hsa-mir-302c-3p
;
hsa-mir-302b-3p
;
hsa-mir-302a-3p
;
hsa-mir-3653-3p
;
hsa-mir-299-5p
;
hsa-mir-4511
;
hsa-mir-548b-3p
;
hsa-mir-6863
;
hsa-mir-210-3p
;
hsa-mir-4776-5p
;
hsa-mir-3619-3p
;
hsa-mir-3654
;
hsa-mir-6720-5p
;
hsa-mir-6512-3p
;
hsa-mir-2682-3p
;
hsa-mir-6877-3p
;
hsa-mir-6819-3p
;
hsa-mir-548c-3p
;
hsa-mir-4659b-3p
;
hsa-mir-4659a-3p
;
hsa-mir-6875-3p
;
hsa-mir-744-3p
;
hsa-mir-6868-3p
;
hsa-mir-3667-3p
;
hsa-mir-6734-3p
;
hsa-mir-5096
;
hsa-mir-3187-3p
;
hsa-mir-4435
;
hsa-mir-588
;
hsa-mir-4701-5p
;
hsa-mir-548s
;
hsa-mir-197-3p
;
hsa-mir-6131
;
hsa-mir-4755-3p
;
hsa-mir-302a-5p
;
hsa-mir-3663-5p
;
hsa-mir-3653-5p
;
hsa-mir-627-3p
;
hsa-mir-4742-5p
;
hsa-mir-4433a-3p
;
hsa-mir-181d-5p
;
hsa-mir-181c-5p
;
hsa-mir-181b-5p
;
hsa-mir-181a-5p
;
hsa-mir-1197
;
hsa-mir-4436a
;
hsa-mir-4459
;
hsa-mir-4519
;
hsa-mir-4779
;
hsa-mir-5000-3p
;
hsa-mir-92a-2-5p
;
hsa-mir-129-5p
;
hsa-mir-2113
;
hsa-mir-329-5p
;
hsa-mir-4464
;
hsa-mir-4748
;
hsa-mir-5010-3p
;
hsa-mir-6509-5p
Nearest miRNA
hsa-mir-1286/Upstream/2142922; hsa-let-7a-3/Downstream/682108;
Nearest TSS
ENST00000624155/Upstream/86301;
ENST00000489500/Downstream/46150;
Nearest CpG islands
None/Target,
chr22-CpG: 279/Upstream/85969
,
chr22-CpG: 31/Downstream/214624
Upstream sequence
AAAGTGGAGGCAGGAAGAAAGAATGTTAAATTTCACATCAGTTTAGAACGAGCTTTTTTTCCCTGAATGGTCACCAGATTGCAATTTTGTATGACCTAAC
Downstream sequence
AAATTTCTCAAAGAGAGTTCTGCTATTGTTGTGAAAGCTTCTATTGTAAATGCTGAAGGAAGACAAGTTGACAGAGTTTTTGTTAATGTAAAACTTCAGA
Target sequence
CTCCTTAAACTATTATTTATTCTTTGTTTTAATTATTGGAGCTCCAACCACTTAAAGTGGAGGCAGGAAGAAAGAATGTTAAATTTCACATCAGTTTAGAACGAGCTTTTTTTCCCTGAATGGTCACCAGATTGCAATTTTGTATGACCTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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