Basic Information
VIS ID
TVIS30016089
Fusion event
HIV-MRTFA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
40862945/40466941 (Hg38)
End
40862725/40466941 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MRTFA
miRNAs that regulate target gene
hsa-mir-183-5p
Nearest miRNA
hsa-mir-1286/Upstream/2478088; hsa-let-7a-3/Downstream/346942;
Nearest TSS
ENST00000624155/Upstream/3507; ENST00000417123/Downstream/54859;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/47843, chr22-CpG: 107/Downstream/169184
Upstream sequence
AAATTTAAATTTATGAAAGCTAACACATTTAATAAATTTGATTCAAGTTTTCTGTGGAGATTACAGTAAAGGCATATTCAGCTtatatatacatacacat
Downstream sequence
atacacaaccgtgtatatattatgcatgtatatatatatatatatttatacacacacatataCAGCTCCAGTACAAAGACGAAAGCTTATCTAATAAACC
Target sequence
ATCCAAGAATAATTTTGAAATATTAACCACTAGCCTTCTTAAGTAAACCATATATGAATAGGGCCATAGGGATATTACATAAACTTCTTGATTGAAAAACTTCTTGCTTCATGAACGCAAAAATTTAAATTTATGAAAGCTAACACATTTAATAAATTTGATTCAAGTTTTCTGTGGAGATTACAGTAAAGGCATATTCAGCTtatatatacatacacat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate