Basic Information
VIS ID
TVIS30016101
Fusion event
HIV-BRD1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50205945/49812297 (Hg38)
End
50206267/49812297 (Hg38)
Orient
+
Location type
Intronic
Target gene
BRD1
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-221-3p ; hsa-mir-18a-3p ; hsa-mir-497-5p ; hsa-let-7g-5p
Nearest miRNA
hsa-let-7a-3/Upstream/268831; hsa-mir-12114/Downstream/150569;
Nearest TSS
ENST00000624155/Upstream/6845; ENST00000624617/Downstream/10908;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/9560, chr22-CpG: 44/Downstream/11212
Upstream sequence
ggttcaAGTGGGAGACTGAGGCAGGAGTCATTCTTCACAGATACTGTCCACAAAGACGATCCAAAAGAATCTTACAACATGTTGTATCCATCTACAACAC
Downstream sequence
GTTTAAGTGAAATTAACAGTGTAATTAACGGTGTAAAGAGTCCAAGCTTCCTAAAGGAACACTAATGTCGGGAGGACTCTAACCAGAAGTCTGACAAGGT
Target sequence
ATAGCTAAAAACAAAAATGCTAATTTTAAGAAGTACTATATTAACAAGTGCCTAGAAATAAATCTAATAGACTTTTATGGAGAAAACCATCAGCTTCTATTATGACATTAAAGAAGTCCTAGAGAGagccaggagtcgtggcacatgcctataatcccagctactcaggaggctgaggcatgagactcacttgaactctggaggtggaggctgcagtgaactgagatcatgccactgaactccagcctgggcgac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate