Basic Information
VIS ID
TVIS30016107
Fusion event
HIV-ALG12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50306790/49913142 (Hg38)
End
50306854/49913142 (Hg38)
Orient
+
Location type
Intronic
Target gene
ALG12
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7a-3/Upstream/369676; hsa-mir-12114/Downstream/49724;
Nearest TSS
ENST00000624155/Upstream/3054; ENST00000498354/Downstream/5025;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/26414, chr22-CpG: 54/Downstream/4978
Upstream sequence
TGCTTCTGCAGGAATAAAGGCTGTTGACCCCATGGGGGCTTGCCAGGTGAGGCGGGAGCAGCAGGCTCAGGTGGCGAGAGCTGCCTCACAGGCAGTCGGC
Downstream sequence
GACTCAGACGTCTTAGGCCTGACCTGAGCACCTGCTCTGAGCCGCCATGCCACGGTGATCGAGGGCAGGCAAGACTAACAGACAGCGTTCCTGGGCAGGA
Target sequence
ATTTCTCTTGTACCTGCCGTCACCCCTAATTTCACAGTCAAGAGTGTGGAGGCACAGAGGGGCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate