Basic Information
VIS ID
TVIS30016108
Fusion event
HIV-PPP6R2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50814767/50376338 (Hg38)
End
50814599/50376338 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP6R2
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-149-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-let-7a-3/Upstream/413399; hsa-mir-12114/Downstream/31104;
Nearest TSS
ENST00000624155/Upstream/4266; ENST00000473283/Downstream/43104;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/32758, chr22-CpG: 20/Downstream/30391
Upstream sequence
gagtccatgagtttgaggctgctgtgagctatgattgcaccgctgcactccagcctgggtgacaaagtgaaaccttgtctcaaaaaaacccccagaaaat
Downstream sequence
gaaaacaggaaaaccagtagaaacacttcctcaaagacttcaggtattggaattgttagaaacagactataaaaaaagtgtactttttgtatgtgtgtga
Target sequence
cagttcaggtgtggtggctcatgcctgtaaccccagcatattgggaggctgaggcaggaggatggcttgagtccatgagtttgaggctgctgtgagctatgattgcaccgctgcactccagcctgggtgacaaagtgaaaccttgtctcaaaaaaacccccagaaaat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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