Basic Information
VIS ID
TVIS30016112
Fusion event
HIV-ARSA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
51062321/50623893 (Hg38)
End
51062190/50623893 (Hg38)
Orient
-
Location type
Exonic
Target gene
ARSA
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-665 ; hsa-mir-3162-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-4768-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-106a-3p ; hsa-mir-122-5p ; hsa-mir-1307-3p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-4430 ; hsa-mir-4466 ; hsa-mir-454-3p ; hsa-mir-4638-5p ; hsa-mir-504-3p ; hsa-mir-675-5p
Nearest miRNA
hsa-let-7a-3/Upstream/216369;
Nearest TSS
ENST00000624155/Upstream/567; ENST00000445220/Downstream/1763;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/18180, chr22-CpG: 66/Downstream/3944
Upstream sequence
gaggctgaggcaggagaatccctggaacccgggaggcggaggttgcagtgagcggagatggtaccactgcactctagcctgggcgacagagcgagactcc
Downstream sequence
gtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaacaaaaacaaatctttagagctggggtctcactatgttgcccaggctggtctgaat
Target sequence
gcagcacacacctgtagttccagctactagggaggctgaggcaggagaatccctggaacccgggaggcggaggttgcagtgagcggagatggtaccactgcactctagcctgggcgacagagcgagactcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate