Basic Information
VIS ID
TVIS30016124
Fusion event
HIV-SACM1L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
45761239/45719747 (Hg38)
End
45761328/45719747 (Hg38)
Orient
+
Location type
Intronic
Target gene
SACM1L
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-101-3p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-324-3p ; hsa-mir-92a-3p ; hsa-mir-3692-3p ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-141-5p
Nearest miRNA
hsa-mir-12127/Upstream/857766; hsa-let-7g/Downstream/2129808;
Nearest TSS
ENST00000440867/Upstream/6551; ENST00000471207/Downstream/10856;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29945, chr3-CpG: 80/Downstream/76241
Upstream sequence
CTTACGGTGACACGAATGTAACCTTTTGTATTTTATTTGTTTTCATTATCATTTGATAGCCTTGCTAAGTATTTATCTCCTGCTTCATTGTAATAATTAG
Downstream sequence
GATCATGTTGTTTGCTGGATGTCCGAAAGCACAGCTGAACTCAGTGTAGTTTTCAGTAACCTAACTTAGAAAGTATTTTCTTGTATTGCTTTTAGGTTTT
Target sequence
GTAGGTCTTCCGTGCTTCAGTTACTGTAATTACATTGCAAATGTTAATGTGATACTTGTAGGCTGCTGCTTACTGCTTGAAGAGGAACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate