Basic Information
VIS ID
TVIS30016127
Fusion event
HIV-SETD2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
47076655/47035165 (Hg38)
End
47076752/47035165 (Hg38)
Orient
+
Location type
Intronic
Target gene
SETD2
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-26a-5p ; hsa-mir-199b-5p ; hsa-mir-21-5p ; hsa-mir-186-5p ; hsa-mir-526b-3p ; hsa-mir-199a-5p ; hsa-mir-1289 ; hsa-mir-3198 ; hsa-mir-3658 ; hsa-mir-3667-5p ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4726-3p ; hsa-mir-5702
Nearest miRNA
hsa-mir-12127/Upstream/2173184; hsa-let-7g/Downstream/814390;
Nearest TSS
ENST00000440867/Upstream/27402; ENST00000429315/Downstream/11862;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/25046, chr3-CpG: 172/Downstream/128134
Nearest cancer related gene
SETD2(TSG, No orient, 0)
Upstream sequence
ACTCTGGGTGGTTGGATATAGTAAGGTTTTATGATCATACTTCTCTTACAGTTGATCACAGACAATACTGCCAATTATttagacttgaatgtgtaattac
Downstream sequence
GCTGAGCAGACCTAACTACTACAATAAGCTCATTGTGAAGGCGCCAGCTCCATGGTCAACCCCTCCAGTCCATCTCCAGCAGAGAGCCTTGTAAAAGGCA
Target sequence
cttgggaccttgtatcacttcagattctgatctagcaggtctgggacagggagtgagactctgcatttttaacaggtggtgcctggtgctcttggGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate