Basic Information
VIS ID
TVIS30016139
Fusion event
HIV-ARIH2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
48965866/48928433 (Hg38)
End
48965627/48928433 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARIH2
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-19a-3p ; hsa-mir-93-5p ; hsa-mir-1301-3p ; hsa-mir-342-3p ; hsa-mir-1229-5p ; hsa-mir-1304-5p ; hsa-mir-6134 ; hsa-mir-6769a-5p ; hsa-mir-6806-5p ; hsa-mir-6769b-5p ; hsa-mir-8055 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-7854-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-610 ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-6777-3p ; hsa-mir-5195-5p
Nearest miRNA
hsa-mir-12127/Upstream/284153; hsa-let-7g/Downstream/91715;
Nearest TSS
ENST00000440867/Upstream/654; ENST00000472640/Downstream/14753;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/8928, chr3-CpG: 130/Downstream/61250
Upstream sequence
TTAGTATGGAAATTGTAAAGAATGAACAAAGTTGATTACCCCATCAGCAAGCATTTTATTTAACACATAAGCTAAAACATACCTTTGGATGTCTTGTACC
Downstream sequence
TTAGGCCAGTTATTATCCTATTTACATTTTTTATGATCATTTTGACAGTTTCCCAACAAGCATGTTTCCTTCTCTAACACTGGCCATTATGGGAAATTGG
Target sequence
TAAATGTCTTGAGAGTATACAGATCCCTCTGGTTTGCCCTGAATAGTCATTGCCTTTGGGCTAATGAGCTCATTTGTTTCATGTACTGATTTTAATAATAATTCTTTCTTATGCTTGTATTTCATTGATTTAGGGGGTGTTAGTATGGAAATTGTAAAGAATGAACAAAGTTGATTACCCCATCAGCAAGCATTTTATTTAACACATAAGCTAAAACATACCTTTGGATGTCTTGTACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate