Basic Information
VIS ID
TVIS30016145
Fusion event
HIV-APEH integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
49716238/49678805 (Hg38)
End
49716470/49678805 (Hg38)
Orient
+
Location type
Intronic
Target gene
APEH
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-34a-5p ; hsa-mir-30a-5p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-12127/Upstream/404619; hsa-let-7g/Downstream/127332;
Nearest TSS
ENST00000440867/Upstream/2135; ENST00000469362/Downstream/106;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/3959, chr3-CpG: 122/Downstream/6905
Upstream sequence
TGCCCCCATGTGTGCTACAAGCTGCAGGGGCCTGACTGGTGCCTGAGTAGGGCCCTGGGTGAATTCCCCAGTACCCTAGCCTTCCTTGTAGACTACCCTC
Downstream sequence
TGCCCAGCCACAAAGTCTCATCAGCCCCTTAAAACCCTGCCTGCCCATCCTGGACTCATTTCTCCTGGAGGGGACTGGCTGCCCTGGTGCACCACAGCAG
Target sequence
CCTACCTCCACTCCTGGATGCAGCCTCAGCCCTCCTATCTTTACAGAGAACTTCTCTGGGATCTACTGCAGCCTTCTGCCTTTGGGATGCTGGTCAGCTGACAGCCAGAGAGTGGTCTTTGACTCGGCTCAGCGCAGCCGGCAGGTGAGGGACGCTGATTGTGTTGAGGGGCAGCCCCTGTGGTCAACCCCCAGGAGCCCTGGGGGTTGCATGTGCATGCCCCTGGGTGGAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate