Basic Information
VIS ID
TVIS30016149
Fusion event
HIV-RBM6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
50076936/50039503 (Hg38)
End
50077060/50039503 (Hg38)
Orient
+
Location type
Intronic
Target gene
RBM6
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-221-3p ; hsa-let-7a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12127/Upstream/233258; hsa-let-7g/Downstream/187933;
Nearest TSS
ENST00000440867/Upstream/40051; ENST00000466247/Downstream/7606;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/98740, chr3-CpG: 69/Downstream/49316
Nearest cancer related gene
RBM6(TSG, No orient, 0)
Upstream sequence
taattttgtacttgtagtagagacagggtttcaccatgttggccaggctggtctcgaactcctgacctcaggtgatccaccccccccccccccacccttg
Downstream sequence
TACAAAATTATAACAAGCTGAAAAGTTTTTTAAAAATCTGCATTTTAGTGGTTCAGTTTTTCAGTTGTTCTGAGTGCTAATAGTTGGAGTTTATAAATTG
Target sequence
gtctcccaaagtgctgggattacaggcatgggccaccgcacccagcATACGGAAATAAATTATTAACCAGAGAAATTTTGACTAAGGTTTTTATAAATGTTAGGTGAACCATTGCTCTAAAAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate