Basic Information
VIS ID
TVIS30016150
Fusion event
HIV-RBM5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
50148455/50111022 (Hg38)
End
50148216/50111022 (Hg38)
Orient
-
Location type
Intronic
Target gene
RBM5
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-320b ; hsa-mir-186-5p ; hsa-mir-17-3p ; hsa-mir-17-5p ; hsa-mir-218-5p ; hsa-mir-4448
Nearest miRNA
hsa-mir-12127/Upstream/304777; hsa-let-7g/Downstream/116414;
Nearest TSS
ENST00000440867/Upstream/3541; ENST00000474470/Downstream/1042;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/21251, chr3-CpG: 132/Downstream/43516
Nearest cancer related gene
RBM5(TSG, No orient, 0)
Upstream sequence
GATTGTAAGTTTTAATTGTAGGGTTAAAAAATGTTttgaggtataatatacacacaaaaaaatacacaaaacagaaatgtgcaattctttgaatgtttat
Downstream sequence
acatgtctatacatttgtatattacatgtgtatatacaccaccacttattcccagcccacctaatcctcatgcccattgctggtcagtaacctatgtctt
Target sequence
TTTCCTCCTCAATTTCACTAGAAGTAGTTTCGCTTAGTGCATTTATGAGGCATAAAATGAAATATTTCCTGCAAAAGAATATATGACTCAGATTAGTTTTAACTTCTTCAAAGCCACCAAAATGTAATTTTTATATGGAGATTGTAAGTTTTAATTGTAGGGTTAAAAAATGTTttgaggtataatatacacacaaaaaaatacacaaaacagaaatgtgcaattctttgaatgtttat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate