Basic Information
VIS ID
TVIS30016157
Fusion event
HIV-RBM15B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
51434777/51397346 (Hg38)
End
51434905/51397346 (Hg38)
Orient
+
Location type
Exonic
Target gene
RBM15B
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-222-3p ; hsa-mir-182-5p ; hsa-mir-34a-5p ; hsa-mir-197-3p ; hsa-mir-4724-3p ; hsa-mir-3667-3p ; hsa-mir-6886-5p
Nearest miRNA
hsa-mir-12127/Upstream/722183; hsa-let-7g/Downstream/870932;
Nearest TSS
ENST00000440867/Upstream/6078; ENST00000602430/Downstream/86492;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4040, chr3-CpG: 76/Downstream/101980
Upstream sequence
ACAGGGTGGGGCGGGTGAGTGAAAAGGTGGAAATCCCTGGTACCTTGCCTGGTGGTTACACAGTTTAACCATAGGCCAATTTTAGGGGCCTCTGAAGTAT
Downstream sequence
CTCCTTAGCTTTGCCAACTCCATCCTCCAAAACTTCCCAGAATACCTCCCTTTCCAGTTCTACCAAATCTGTACTTGGGAGCAGCCTGCTGGATCCAGAA
Target sequence
CTTTCTACAAACGCAGACAAGCTCCACTACCCCTAACCTGCCAGGATGCTCAAGTCCACTGTCACAATCCCTTTCAGAAAACATTAGTGGCCGCTGCCCCAGCTACAGAGACGGCCGAAATGCTTTCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate