Basic Information
VIS ID
TVIS30016160
Fusion event
HIV-DCAF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
51484268/51450252 (Hg38)
End
51484366/51450252 (Hg38)
Orient
+
Location type
Intronic
Target gene
DCAF1
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12127/Upstream/775089; hsa-let-7g/Downstream/818026;
Nearest TSS
ENST00000440867/Upstream/58984; ENST00000602430/Downstream/33586;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/56946, chr3-CpG: 76/Downstream/49074
Upstream sequence
ttaagcaacaaaaccagacccatctctttaaataattaaataaaataaagaagaattaacaccaatccttctcataactcttcccaaaaattgactggga
Downstream sequence
agttataaaaatcctcaacaaaatactaggaaaatgaattcagcagcataagaggattatacatcatgactaaataaactaaatctcaggaattcaaaga
Target sequence
ggtaacacttcctaactcattttatgatgccagcattaccaaagctaaagacactgtgagaaaacaaaactatagaccaatatatcactcatgactat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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