Basic Information
VIS ID
TVIS30016167
Fusion event
HIV-UBA3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
69112258/69063107 (Hg38)
End
69112453/69063107 (Hg38)
Orient
+
Location type
Exonic
Target gene
UBA3
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-let-7g/Upstream/14072; hsa-mir-12124/Downstream/2478863;
Nearest TSS
ENST00000440867/Upstream/10768; ENST00000485444/Downstream/984;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/10594, chr3-CpG: 44/Downstream/16800
Upstream sequence
ATTCGATACAAGCAGTCATTCCAGGCAGAATCACCCGGGCATTTCCTTTAAAACCTTCTGTCCCCCCATCTATCAAAGGGACAATGGAGCTTGGATCTAA
Downstream sequence
GCAATAAACAATGAAGTAAATATACTTAATTAAAAATTAAACTCTGATTTTTCAAAAATATATCAATTCTAATTTTGGGGATGTGAAGCACAGCAGCAAG
Target sequence
GACACCATCTTCATAATTTAGAAGAGATATCTAGGAAAACAATTTGAAGGGCTTTAAAGGAGAAGGGGATAAGAATTCAAAAGAAGAAGTATGCTTTCAAGTAATCCTATGAGTCGGTTGTGCTATTGAATACCAATGTATCAAATCAAGGGATTATAATAACAATTTGTGTCTTCACCTGAAAACCAATGACTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate