Basic Information
VIS ID
TVIS30016169
Fusion event
HIV-TFG integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
100450950/100732106 (Hg38)
End
100450796/100732106 (Hg38)
Orient
-
Location type
Intronic
Target gene
TFG
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-106a-5p ; hsa-mir-92a-3p ; hsa-mir-142-3p
Nearest miRNA
hsa-let-7g/Upstream/767708; hsa-mir-12124/Downstream/2791927;
Nearest TSS
ENST00000440867/Upstream/18420; ENST00000481203/Downstream/10370;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22281, chr3-CpG: 48/Downstream/780660
Nearest cancer related gene
TFG(OG, No orient, 0)
Upstream sequence
TGGCTTGATTTCCATGTAATTTAATAGTGGACCAGTAGACAGTAGAAATAAAATGTAAAATTTGAGATTATAACCTTAGTTCAGTTTCTTTTTATAAAAT
Downstream sequence
AAAGCCTTAGTTCCTATAATTATTTTTTCCAGAGTGCCCAGTGGGTATCTGATACTAGGATATAGGTTATTGGGCTCCAAAAAAACCAAAAAAAGTAAAA
Target sequence
ATTCAAAAATGTTTTTAATGTGCTATTTATGGAAGATTATGAATTAATTATGGTTGGCTTGATTTCCATGTAATTTAATAGTGGACCAGTAGACAGTAGAAATAAAATGTAAAATTTGAGATTATAACCTTAGTTCAGTTTCTTTTTATAAAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate