Basic Information
VIS ID
TVIS30016174
Fusion event
HIV-ARHGAP31 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
119112469/119393622 (Hg38)
End
119112362/119393622 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGAP31
miRNAs that regulate target gene
hsa-mir-6770-3p ; hsa-mir-6825-5p ; hsa-mir-4730 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-7106-5p ; hsa-mir-149-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-663a ; hsa-mir-6787-5p ; hsa-mir-1908-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6760-5p ; hsa-mir-3680-3p ; hsa-mir-576-5p ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-4735-5p ; hsa-mir-133a-5p ; hsa-mir-138-5p ; hsa-mir-3189-5p ; hsa-mir-3692-5p ; hsa-mir-4758-3p ; hsa-mir-544a ; hsa-mir-548q ; hsa-mir-5699-5p ; hsa-mir-6071 ; hsa-mir-6131 ; hsa-mir-6738-3p ; hsa-mir-6828-3p ; hsa-mir-93-3p
Nearest miRNA
hsa-let-7g/Upstream/2543255; hsa-mir-12124/Downstream/690942;
Nearest TSS
ENST00000440867/Upstream/68730; ENST00000390401/Downstream/43194;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/70214, chr3-CpG: 24/Downstream/8378
Upstream sequence
CTGGATCAGACTCCAAATCAAAACTGAGTAGAAATGGGAGTGTATTTGTGAGAGGACAGAGGCTCTCGGGTAAGAATCAACAGCAATTGTTTTATGATAC
Downstream sequence
AAATATTTGTTTCCTAACTCTGCTTATTAAGTCTTTGGTTTGATCATATCAAACACACTAGCTCTGAAAGAGAAACTTATAAATTAACTAGGGGAAGAGG
Target sequence
GGACGTTCTGGATCAGACTCCAAATCAAAACTGAGTAGAAATGGGAGTGTATTTGTGAGAGGACAGAGGCTCTCGGGTAAGAATCAACAGCAATTGTTTTATGATAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate