Basic Information
VIS ID
TVIS30016177
Fusion event
HIV-RAB7A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
128457930/128739087 (Hg38)
End
128458043/128739087 (Hg38)
Orient
+
Location type
Intronic
Target gene
RAB7A
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-299-3p ; hsa-mir-6748-5p ; hsa-mir-6759-5p ; hsa-mir-6847-3p ; hsa-mir-6881-5p ; hsa-mir-6835-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-6797-5p ; hsa-mir-3153 ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-5681a ; hsa-mir-6783-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-561-5p ; hsa-mir-6830-5p ; hsa-mir-2355-3p ; hsa-mir-676-3p ; hsa-mir-5590-5p ; hsa-mir-3124-5p ; hsa-mir-6793-5p ; hsa-mir-4437 ; hsa-mir-5580-5p ; hsa-mir-6882-3p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-3607-5p ; hsa-mir-3614-3p
Nearest miRNA
hsa-let-7g/Upstream/1151911; hsa-mir-12124/Downstream/107721;
Nearest TSS
ENST00000440867/Upstream/12735; ENST00000464496/Downstream/56156;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12280, chr3-CpG: 55/Downstream/140246
Nearest cancer related gene
RAB7A(TSG, No orient, 0)
Upstream sequence
cttaagatcctttcgtattttgacattctctgactctTGGACATACTGCTGTGGCTTTTGCAACATCCTAACTGGTTAGTTGACACCATCAGAAACTTTA
Downstream sequence
CAGAAGCAGTATAAAAGTCTTAAAGCGggccgggagtggtggctcacgcctgtaatctcagcagtttggaaggctgaggtgggcggatcacctgaggtca
Target sequence
AGGACCCTGTTAGCCATTGAGTATATGGAGCTTTGCCCATTCGTTTCTGAGAGGCAAGAGGCACTGGTAGGCAGTTAGATTTTTCTTTAAAATGTGTACTCGTTTCTAAATTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate