Basic Information
VIS ID
TVIS30016191
Fusion event
HIV-TP63 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
189376555/189658766 (Hg38)
End
189376498/189658766 (Hg38)
Orient
-
Location type
Intronic
Target gene
TP63
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-21-5p ; hsa-mir-124-3p ; hsa-mir-301b-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-4477b ; hsa-mir-1178-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428
Nearest miRNA
hsa-let-7g/Upstream/969900; hsa-mir-3137/Downstream/171156;
Nearest TSS
ENST00000440867/Upstream/27250; ENST00000434928/Downstream/130894;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/711003, chr3-CpG: 99/Downstream/461525
Nearest cancer related gene
TP63(TSG, No orient, 0)
Upstream sequence
gctcctcaaaattttaaatgtcatcaaaacatggaaaatttgaaaaactgttgtaactaagagccaaatgagatatgatgaataaacataatgtggtatc
Downstream sequence
ctgtatggaatttaggagaagaaaaaggagataagcaaaactaaggaaatatgaataaattatgggactttagcctatctaactcagttggtagagaatg
Target sequence
aaaactgttgtaactaagagccaaatgagatatgatgaataaacataatgtggtatc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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