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TVIS30016198
Basic Information
VIS ID
TVIS30016198
Fusion event
HIV-PAK2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
196543500/196816629 (Hg38)
End
196543751/196816629 (Hg38)
Orient
+
Location type
Intronic
Target gene
PAK2
miRNAs that regulate target gene
hsa-mir-155-5p
;
hsa-mir-500a-3p
;
hsa-mir-193b-3p
;
hsa-mir-15a-5p
;
hsa-mir-16-5p
;
hsa-mir-15b-5p
;
hsa-mir-195-5p
;
hsa-mir-424-5p
;
hsa-mir-497-5p
;
hsa-mir-298
;
hsa-mir-922
;
hsa-mir-548e-5p
;
hsa-mir-1253
;
hsa-mir-4311
;
hsa-mir-6838-5p
;
hsa-mir-944
;
hsa-mir-3120-3p
;
hsa-mir-3163
;
hsa-mir-4698
;
hsa-mir-5692a
;
hsa-mir-8063
;
hsa-mir-3133
;
hsa-mir-3925-5p
;
hsa-mir-8084
;
hsa-mir-302a-3p
;
hsa-mir-302b-3p
;
hsa-mir-302c-3p
;
hsa-mir-302d-3p
;
hsa-mir-372-3p
;
hsa-mir-373-3p
;
hsa-mir-520e
;
hsa-mir-520f-5p
;
hsa-mir-519c-3p
;
hsa-mir-520a-3p
;
hsa-mir-519b-3p
;
hsa-mir-520b
;
hsa-mir-520c-3p
;
hsa-mir-520d-3p
;
hsa-mir-519a-3p
;
hsa-mir-302e
;
hsa-mir-4799-5p
;
hsa-mir-224-5p
;
hsa-mir-218-5p
;
hsa-mir-1273e
;
hsa-mir-636
;
hsa-mir-648
;
hsa-mir-4773
;
hsa-mir-595
;
hsa-mir-658
;
hsa-mir-219b-3p
;
hsa-mir-6840-3p
;
hsa-mir-7846-3p
;
hsa-mir-302f
;
hsa-mir-5692c
;
hsa-mir-5692b
;
hsa-mir-369-3p
;
hsa-mir-625-3p
;
hsa-mir-429
;
hsa-mir-200c-3p
;
hsa-mir-200b-3p
;
hsa-mir-6502-5p
;
hsa-mir-1301-5p
;
hsa-mir-4786-5p
;
hsa-mir-4307
;
hsa-mir-6502-3p
;
hsa-mir-6512-5p
;
hsa-mir-4646-3p
;
hsa-mir-4433b-5p
;
hsa-mir-580-3p
;
hsa-mir-1287-3p
;
hsa-mir-7976
;
hsa-mir-4766-5p
;
hsa-mir-345-3p
;
hsa-mir-6779-3p
;
hsa-mir-4687-5p
;
hsa-mir-129-1-3p
;
hsa-mir-129-2-3p
;
hsa-mir-27b-3p
;
hsa-mir-27a-3p
;
hsa-mir-134-5p
;
hsa-mir-137
;
hsa-mir-1273g-3p
;
hsa-mir-3160-3p
;
hsa-mir-4487
;
hsa-mir-4793-3p
;
hsa-mir-558
;
hsa-mir-5694
;
hsa-mir-668-3p
;
hsa-mir-6890-3p
;
hsa-mir-7703
;
hsa-mir-96-3p
Nearest miRNA
hsa-let-7g/Upstream/934234; hsa-mir-4797/Downstream/477249;
Nearest TSS
ENST00000440867/Upstream/4411;
ENST00000489744/Downstream/51227;
Nearest CpG islands
None/Target,
chr3-CpG: 148/Upstream/76147
,
chr3-CpG: 101/Downstream/51076
Upstream sequence
TGTGCCAGAACTTTTAAACTGTGACGAGTTTGTTTCTATTTATTTGTACAAGTATTTTCTGGAGCTTTGAATCTGATGATTGCCTGGTAAATGTATTGCG
Downstream sequence
TTATTCTTGCATCATTCATGTCCAAGTTGTAGATACAGCTTAATATAAAATCGGGCACTGAAGAACATCTTCTTTCTGATGAACAGCTAAGTGGAACCAG
Target sequence
GTAACACCCAATTTATCTGTTTTTCCTTGAATGAATAGTAGAAGATTTTGGATGAGATTTTTAGTTGTACAGACTTTGTTCTCCTCTGATGGGAGTAAGAAATAAAAGCACAGCTAACTTACACCCGTAGTTCAAAAACACAAGAGTGAGCAGATTTTTAAAACGTCATCTCGTTCTCGTTTGTAAGGAAAGGAGTAGTTTACCCCCACTTTGTGACTCAGTGCTCTCTGAAATATGGCATAAGAGGAAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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