Basic Information
VIS ID
TVIS30016206
Fusion event
HIV-DLG1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
196805652/197078781 (Hg38)
End
196805546/197078781 (Hg38)
Orient
-
Location type
Intronic
Target gene
DLG1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-9-3p
Nearest miRNA
hsa-let-7g/Upstream/1196386; hsa-mir-4797/Downstream/215097;
Nearest TSS
ENST00000440867/Upstream/2910; ENST00000414529/Downstream/6877;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/48278, chr3-CpG: 115/Downstream/218775
Nearest cancer related gene
DLG1(TSG, No orient, 0)
Upstream sequence
AGATAGACGAGAAAGTGTTTTAGTGAAAAAAATTATGGTAATCTAATTTAGGGAAAAACTAAATCTTTTCGTTCATAAGAATCAATGGTTTTGAATTTAG
Downstream sequence
CAATAATTTTTATATCTGATACAACTGATGTGTTTTTTATAAAAGTTTATTCATCCCTCTTACTGCATCTATAGTGGTCAGAGTCAGTTTCACAGCAAAC
Target sequence
GAAAGGAGATAGACGAGAAAGTGTTTTAGTGAAAAAAATTATGGTAATCTAATTTAGGGAAAAACTAAATCTTTTCGTTCATAAGAATCAATGGTTTTGAATTTAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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