Basic Information
VIS ID
TVIS30016209
Fusion event
HIV-ZNF141 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
348186/354397 (Hg38)
End
348039/354397 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF141
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-1273e ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-4722-5p ; hsa-mir-6134 ; hsa-mir-219b-3p ; hsa-mir-4740-3p ; hsa-mir-4768-3p ; hsa-mir-302f ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6078 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-25-5p ; hsa-mir-3160-3p ; hsa-mir-4324 ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-558 ; hsa-mir-6087 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-658 ; hsa-mir-6761-5p
Nearest miRNA
hsa-mir-571/Upstream/4145; hsa-mir-12113/Downstream/1631987;
Nearest TSS
ENST00000502981/Upstream/16562; ENST00000579770/Downstream/23642;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/16118, chr4-CpG: 38/Downstream/31713
Upstream sequence
AACACAGCATGCCCAAGGTCACCCTGCAGGTGCCTAAGTCCAGGGCCTGCTGGAAATCAGGTTTCTATGAGTTCAAGGCAAAGTTTTTGGGTGTGGTTAT
Downstream sequence
tgtaaatgtaaatgcaaaatagaaataagaggcttaatcctcacattggaaaataaagagtatttactctcctcccttttcttaaaacctttgatttaga
Target sequence
ACCTTTTCTTATTCTGCATTTTCCCCCCACAGACCCTCTCTCATGTGAACACAGCATGCCCAAGGTCACCCTGCAGGTGCCTAAGTCCAGGGCCTGCTGGAAATCAGGTTTCTATGAGTTCAAGGCAAAGTTTTTGGGTGTGGTTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate