Basic Information
VIS ID
TVIS30016210
Fusion event
HIV-TMEM175 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
928788/935000 (Hg38)
End
928709/935000 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM175
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-585-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-181c-3p
Nearest miRNA
hsa-mir-571/Upstream/584748; hsa-mir-12113/Downstream/1051384;
Nearest TSS
ENST00000502981/Upstream/2483; ENST00000502513/Downstream/13411;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2300, chr4-CpG: 48/Downstream/11825
Upstream sequence
gaccttatgtatttattggaatgaaggtgaaggaattctctaatgacttctgttttcattgtgaatgaggaaagaaaaacatcaactgaaagtgagaggg
Downstream sequence
gaagtaggaaacccaagatttaagcagtgtcaaaaagatctaaaatagctattatgagaAACCTAGCAAATAACTCACTGGAAAGCATGAGAGCGTTTAA
Target sequence
tgaaggtgaaggaattctctaatgacttctgttttcattgtgaatgaggaaagaaaaacatcaactgaaagtgagaggg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate