Basic Information
VIS ID
TVIS30016214
Fusion event
HIV-MAEA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
1319252/1325464 (Hg38)
End
1319601/1325464 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAEA
miRNAs that regulate target gene
hsa-mir-455-3p
Nearest miRNA
hsa-mir-571/Upstream/975212; hsa-mir-12113/Downstream/660920;
Nearest TSS
ENST00000502981/Upstream/15677; ENST00000512289/Downstream/3593;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/9835, chr4-CpG: 16/Downstream/846
Upstream sequence
CTTGTTGGCGCTCCACGCCGTATGGGACAGTGTAGACTCGGTGTTTTAGATTTGGGTCTGAATACCTAAGTTTCACGACATAGACACACTTACATATTAG
Downstream sequence
CTTTGTGCCTCTCGGCTGATTTGTACCAAGCCTGGCACTCCCCACCCAGAGCCTGTGCCACTGCTGGGGTCAGAGACAGTCCTCCTGCCCCAGCTTGGAG
Target sequence
TGGACCAATTGAAAGTAACCTACTAGAGCAAAAGGTGTTATTGAAAAGCAGGTTTGAGGTGTCTATTGTGTGAAGCGGTAACCTAGAGTGGGCCCAGAGTCCTGCTCTTCTAGAGCACCCCCTCGGCAGCTGCGTCCTGCCTTTAGACAGAGCCCCGGCACTCGCCTGCTCTAGACACGGCAGCCATCAGGCAGCCCCTGGGAGGCAGGTGGGGCCCTGGTGGGGAGCCTCTATCTCTTCCCGCTGGCCCTTCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate