Basic Information
VIS ID
TVIS30016218
Fusion event
HIV-SEL1L3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
25842215/25840593 (Hg38)
End
25842134/25840593 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
SEL1L3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-mir-93-3p ; hsa-let-7a-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-486-5p ; hsa-mir-339-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-520f-5p ; hsa-mir-6780a-3p ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183
Nearest miRNA
hsa-mir-12113/Upstream/1320303; hsa-mir-1243/Downstream/2978989;
Nearest TSS
ENST00000502981/Upstream/61390; ENST00000522137/Downstream/20038;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/164083, chr4-CpG: 123/Downstream/21545
Upstream sequence
TCCATTGGATCTGAAGATGAGAATGCATTTTTGAAACGAAAAGAGTGGAGAAGAAGAAAACTGCCATGTTGCCCCAGAGTTTCTTATTTAAGAGGGAAGA
Downstream sequence
TCAGAGAAGTGTTCATAAAGCTAAACATTAGGGCATTTAAGAACCTTCCAAGAGTGTTCCTAAACTGCTTATCCAGTCTTACTTCTTGAATTGCCCATGT
Target sequence
AGAATGCATTTTTGAAACGAAAAGAGTGGAGAAGAAGAAAACTGCCATGTTGCCCCAGAGTTTCTTATTTAAGAGGGAAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate